To get comments or suggestions from statisticians, it would be easier if you show a plot of data (response vs. predictors) on which locfit or loess is applied. Depending on data and the objective of the study, various approaches to local regression or smoothing are available. It’ll be nice to show people the looks of measurement errors (how they are associated with data) as well as two sets (approaching from a mixture model of two components or just providing proportions to pool the uncertainty) to derive the appropriate model.
Graphics for diagnostics and modeling direction/assumption prior to any comments.

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