No configuration file for you! 0) Install R and cfitsio, determine locations of fitsio.h, R.h, Rinternals.h libcfitsio.so, libR.so (Note: you may have to edit the Makefile for cfitsio to force it to make a shared library.) 1) Edit Makefile 2) "make shared" 3) Move librfits.so to desired library location 4) Edit first lines of rfits.r to point to libcfitsio.so and librfits.so 5) See rfits.API for list of RFITS functions and their arguments